Andrew Wilson, PhD
Prognostic Significance of TR3/NR4A1 Expression in Ovarian Cancer
A key clinical problem in the management of advanced ovarian cancer is tumor resistance to traditional platinum drugs and to newer drugs that inhibit the PARP protein (PARPi). Dr. Wilson will investigate an innovative approach to improve the effects of platinum drugs and PARPi. He has shown that the TR3 protein, which kills ovarian cancer cells, is reduced in tumors resistant to these platinum and PARPi drugs. By activating TR3 function in ovarian cancer cells that are being treated with platinum drugs and PARPi, he hopes to improve drug response and benefit a large number of women with advanced disease.