Christina Annunziata, MD, PhD
National Cancer Institute
Characterization of NF-kB signaling as a therapeutic target in ovarian cancer
The NF-kB family of transcription factors has been implicated in the increase of ovarian cancer cell lines, but the significance and the mechanism of signaling is unknown. Initial experiments identified a subset of ovarian cancer cell lines that are dependent on NF-kB signaling for growth and survival. Dr. Annunziata, with the guidance of her mentor, Dr. Elise Kohn, will investigate the hypothesis that constitutive NF-kB signaling defines a subset of ovarian cancer susceptible to therapeutic targeting of this pathway.