Daniela Dinulescu, PhD
Eugene Braunwald Research Center, Harvard Medical Center
Targeted therapeutic strategies and early detection biomarkers in ovarian cancer
Epithelial ovarian cancer is the leading cause of death among gynecological cancers. We will actively discover, identify and validate disease biomarkers associated with early disease. The data collected from these key preclinical studies will be instrumental in designing successful clinical trials involving novel, molecularly targeted therapies and screening means for early detection. This work will allow us to test the efficacy of targeted therapies in ovarian cancer, improve the chemotherapies currently used, and better understand the mechanism of tumor chemoresistance. A sustained research effort in the areas of screening and treatment will dramatically improve the prognosis of ovarian cancer patients, as has been proven in other women’s cancers, such as breast and cervical cancers.