Iain McNeish, MD, PhD, FRCP
University of Glasgow
Improved models of high grade serous ovarian cancer
To understand how cancers grow and spread within patients, it is essential that researchers have realistic and simple animal models that accurately recreate the mutations seen in the DNA of human cancers. Dr. McNeish will use a new technique, called CRISPR/Cas9 gene editing, to alter the DNA in a mouse model of ovarian cancer, specifically creating mutations seen in human high grade serous ovarian cancer. This new mouse model will used to identify key abnormalities in the DNA of tumor cells that drive changes in the environment surrounding the tumor, especially the interactions with the immune system.