Kwong-Kwok Wong, PhD
University of Texas MD Anderson Cancer Center
To investigate invasion determinants in low-grade ovarian serous cancer
Low-grade ovarian serous carcinomas (OSCs) appear to be a continuum from borderline tumors, and is often resistance to chemotherapy. The possible progression from borderline tumor to low-grade OSC will involve the acquisition of the ability to invade or destroy the underlying tissues. In this study, we will test a set of highly expressed genes (potential therapeutic targets) to determine their involvement in the invasive characteristics of low-grade ovarian cancer.