Mark Poznansky, MD, PhD
Massachusetts General Hospital
Antagonism of SDF-1 production by ovarian cancer and tumor immune control
Immune cell migration into ovarian cancer is an important way in which the tumor is recognized as abnormal and killed by the immune system. Ovarian cancer tumors produce high amounts of a protein called SDF-1, thereby preventing immune cells to protect the body against the disease. This proposal aims to block the production of SDF-1 by ovarian cancer and thereby allow immune cells to eradicate the tumor.