Shailendra Giri, PhD
Mayo Clinic
S-nitrosylation mediated inactiviation of TSG in ovarian cancer
Chronic inflammation has become a well-accepted risk factor for epithelial-derived malignancies, including ovarian cancer. But how inflammation contributes to the process of carcinogenesis is a grey area. If successful, Dr. Giri’s study will elucidate the possible novel regulation of chemical inactivation of LKB1-AMPK pathway by inflammatory mediators in ovarian cancer and lead to a better understanding of the inflammation mediated mechanisms and open up new therapeutic approaches to control inflammation which is an under investigated area of ovarian cancer.