Simon Chu, PhD
PPARgamma Activation Augments Anticancer Effects of XIAP Inhibition in Ovarian Granulosa Cell Tumors
Granulosa cell tumors of the ovary arise due to dysfunction of the granulosa cells, which are support cells in the ovary, involved in ovulation and production of hormones. Dr. Chu will determine if using therapeutic drugs that act on critical cell signaling pathways, involving key genes for cell survival, will render these tumors more sensitive to chemotherapy. By identifying and manipulating unusual and distinctive patterns of key cell survival genes, he can develop tools for better prognostic indicators and potential new targets for granulosa cell tumor treatments.