Xiaohong (Mary) Zhang, PhD
University of South Florida, College of Medicine
Mechanisms by which HDAC inhibitors sensitize cisplatin resistant ovarian cells
Overcoming platinum-resistance in ovarian cancer patients remains a great challenge. Recently, histone deacetylase (HDAC) inhibitors are being used to minimize resistance. HDAC6 may confer the cisplatin-resistance by down-regulating a DNA repair complex. Dr. Zhang will investigate three aspects by which HDAC inhibitors sensitize cisplatin resistant ovarian cells and may identify HDAC6 as a therapeutic target for platinum-resistance in ovarian cancer.