David Bowtell, PhDPeter MacCallum Cancer Center2011–2013 Lester and Bernice Smith Fellow Challenge Grant Award Recipient – 2011 Circulating TP53 mutations as a biomarker of high-grade serous cancer In his proposed project, Dr. Bowtell will use the latest, most sensitive DNA sequencing techniques to study whether ovarian cancer tumors give off enough DNA into circulating blood […]
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Martin Matzuk, MD, PhDBaylor College of Medicine 2013 Challenge Grant Award Recipient Molecular Imaging of the Dicer/Pten Mouse Model Tumor Microenvironment Dr. Matzuk’s project will use Dicer-Pten mutant mice, which closely model human high-grade serous carcinoma with tumors arising in the fallopian tubes. A state-of-the-art tissue-based mass spectrometry imaging platform will provide the approach for […]
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André Lieber, MD, PhDUniversity of Washington2016 Lester and Bernice Smith Challenge Award Grant Immuno-Prophylaxis of Ovarian Cancer Associated with High-Risk Germ Line Mutations Dr. Lieber’s project proposes a prophylactic gene therapy approach to introduce genes encoding antibodies into hematopoietic stem cells from the bone marrow. Ovarian cancer cells normally produce signals that inhibit immune cells […]
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