Shannon Hawkins, M.D., Ph.D.Indiana UniversityIndianapolis, IN, United States Project: Dissecting the role of ARID1A in ovarian cancer using a 3D bio-assembled model of the endometriotic tumor microenvironment Research Areas: Cancer Biology Summary:Endometriosis, growth of uterus tissue outside the uterus, effects 5 million women in the US and is associated with a 50% increase in the risk of […]
Read MorePamela K Kreeger, Ph.D.University of Wisconsin-MadisonMadison, WI, United States Project: Role of P-selectin in transcoelomic spread of ovarian cancer Research Area: Cancer Biology, Novel Therapy Summary:In high grade serous ovarian cancer, metastasis or spread of the cancer occurs when tumor cells break away from the primary tumor, float through the fluid in the abdominal cavity, and attach […]
Read MoreAlvaro Monteiro, Ph.D.H. Lee Moffitt Cancer Center & Research InstituteTampa, FL, United States Project: Tackling PARP inhibitor resistance through functional proteomics Research Areas: Chemotherapy Resistance Summary:There has been significant progress in ovarian cancer treatment especially with the development and approval of PARP inhibitor drugs. Despite this progress, a sizable percentage of patients do not respond or stop […]
Read MoreJohn Liao, M.D., Ph.D.University of Washington2018 James A. Harting Pilot Study Award Development of a vaccine to prevent serous tubal intraepithelial carcinoma High grade serous ovarian cancer does not originate in the ovary, as once thought, but on the fallopian tube. Precancerous fallopian tube cells (called serous tubal intraepithelial carcinoma or STIC) can go through […]
Read MoreSusan J Ramus, PhDThe University of New South Wales Genetic susceptibility to non-high grade serous ovarian cancer Ovarian cancer consists of five distinct types of cancers that have different clinical characteristics, patient outcomes, and even begin in different nearby organs. They have different changes in the DNA of the tumor cells which affect the biology […]
Read MoreDan Peer, Ph.D.Tel Aviv UniversityTel Aviv, Israel Project: Developing a novel therapeutic modality to chemo-resistance epithelial ovarian cancer. Research Areas: Novel Therapy, Chemotherapy Resistance Summary:Chemotherapy resistance is one of the biggest challenges for the treatment of epithelial ovarian cancer. One promising method to reliably test new anticancer drugs and understand response to chemotherapy is to develop 3-dimentional […]
Read MoreAngela Russo, Ph.DUniversity of Illinois at Chicago – UICChicago, IL, United States2018 MARLYS CHENEY PILOT AWARD Project: Characterization and targeting the markers of stemness altered during ovarian cancer pathogenesis using WNT inhibitors Research Areas: Cell Biology, Stem Cells, Tumor Microenvironment Summary:High-grade serous ovarian cancer is the most common type of ovarian cancer with the highest mortality rate. […]
Read MoreHui Zong, PhDUniversity of VirginiaCharlottesville, VA, United States 2019 Pilot Study Award Research in Focus: Prevention of ovarian cancer Efficacy testing for ovarian cancer prevention at pre-malignant stages with a novel mouse model Prevention remains the ultimate goal for successful management of cancer. Identifying cancer prevention strategies is challenging due to the large population required to […]
Read MoreWa Xian, PhDUniversity of Texas Health Science Center at HoustonHouston, TX, United States 2019 Pilot Study Award Research in Focus: Understanding and overcoming resistance to chemotherapy Resistant Cancer Stem Cell Profile in Multi-Site Metastasis of HGSC Even though ovarian cancer is typically detected very late, advances in surgery and chemotherapy have resulted in remarkable responses in […]
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