Rosemary Foster, PhDMassachusetts General Hospital Identification and Characterization of the Ovarian Cancer Stem Cell Cancer stem cells have recently been identified in some solid tumors and are thought to drive tumor formation. Most tumors likely contain rare subpopulations of stem-like cells that would serve as critical targets of more clinically effective therapies. Our research experiments […]
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Melissa Fishel, PhDIndiana University School of Medicine Enhancement of ovarian cancer to chemotherapeutics agents, cisplatin and TMZ, using small molecules, BG and MX With the exception of a small percentage of patients presenting with stage IA/IB ovarian cancer, surgery along is inadequate treatment. However, virtually all patients who die from ovarian cancer have intrinsic or […]
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Elizabeth Smith, PhDFox Chase Cancer Center Suppression of cyclooxygenase in prevention of menopausal gonadotropin-stimulated ovarian cancer risk The risk of developing ovarian cancer increases rapidly in the peri- and post-menopausal periods, when ovulation ceases but the reproductive gonadotropin hormones are elevated. These gonadotropins can induce expression of certain enzymes which stimulate an inflammation-like condition that […]
Read MoreDaniela Matei, MDIndiana University Atransglutaminase 2 Modulates Sensitivity to Chemotherapy in Ovarian Cancer The most significant cause of death and illness related to ovarian cancer is its propensity to spread in the abdomen. However, the mechanisms responsible for spread are not known. We discovered that an enzyme called transglutaminase 2 (TG2) is present at high […]
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Robert Jaffe, MDUniversity of California San Francisco Inhibition of Telomerase to Treat Advanced Ovarian Cancer Telomerase is an enzyme that maintains and protects the ends of chromosomes, the telomeres. While telomerase is constrained in many normal adult cells, a majority of cancers appear to depend on active telomerase for their growth, making this enzyme an […]
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Daniela Dinulescu, PhDEugene Braunwald Research Center, Harvard Medical Center Targeted therapeutic strategies and early detection biomarkers in ovarian cancer Epithelial ovarian cancer is the leading cause of death among gynecological cancers. We will actively discover, identify and validate disease biomarkers associated with early disease. The data collected from these key preclinical studies will be instrumental […]
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