Mary Zhang, PhDUniversity of South Florida Role of HDAC6 and its novel substrate cortactin in ovarian cancer cell motility HDACs are a group of enzymes that regulate cell growth and migration, and hence are likely involved with the metastases of ovarian cancer. This study will examine the role between these enzymes and the molecular events […]
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Hong Zhang, PhDFox Chase Cancer Center Regulated exocytosis and gamma synuclein in ovarian cancer: a biomarker of disease γ synuclein (gamma synuclein) is a protein that may shuttle other proteins which promote the growth and spread of cancer. This study will identify these protein promoters and assess whether γ synuclein could be used in screening.
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Cassian Yee, MDFred Hutchinson Cancer Research Center Cellular Adoptive Immunotherapy in Treating Patients With Stage III or Stage IV Ovarian Cancer Dr. Yee is studying a new technique to treat women with late stage ovarian cancer. T cells are collected from patients and responder cells are enhanced. These are given back to the patient, where […]
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Jill Slack-Davis, PhDUniversity of Virginia Role of VCAM-1 in an orthotopic mouse model of ovarian cancer metastasis It is believed that the vascular cell adhension molecule-1 (VCAM-1) aids in the adhesion and spreading of ovarian cancer in the abdomen and beyond. By defining the role of VCAM-1, this work could lead to a target for […]
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Shu-Wing Ng, PhD, BScHarvard / Brigham and Women’s Hospital Characterization of lipid metabolic enzymes in ovarian cancer This study will confirm the expression and activity of two important enzymes and investigate the effects of inhibiting these enzymes. The results will provide information regarding their role in ovarian cancer and have an impact on screening, surveillance […]
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Lainie Martin, MDFox Chase Cancer Center A pilot study to evaluate the role of STAT3 in angiogenesis, tumor cell proliferation and survival in ovarian cancer This study will look at a family of genes (STAT3) and their impact on the process of cell death. With a greater understanding the role of STAT3, researchers hope to […]
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Fang-Tsyr Lin, MD, PhDUniversity of Alabama at Birmingham Role of TRIP6 in Ovarian Cancer Progression TRIP6 is a novel molecule that helps make cancer cells immortal, thus allowing cancer to grow uncontrolled. This study will determine if silencing TRIP6 can increase the effectiveness of chemotherapy.
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Victor Levenson, MD, PhDNorthwestern University A Composite DNA Methylation Biomarker For Ovarian Cancer Detection This study seeks to find a blood-based DNA pattern (as opposed to a single specific target) that could be used to detect ovarian cancer early.
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Patricia Kruk, PhDUniversity of South Florida Elevated Urinary Bcl-2 in Ovarian Cancer This study seeks to determine whether a simple urine test for a protein called Bcl-2 may serve as a new biomarker for detection of ovarian cancer.
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Zhiyong Ding, PhDThe University of Texas MD Anderson Cancer Center Identification of novel interaction partners of p110 and p85 in ovarian cancer cells Ovarian cancer, like all cancer, is a disease of gene malfunctions. This study will look at a gene known to control cancer cells (PIK3CA) and the proteins it interacts with. These proteins […]
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