Kwan Ho Tang, PhDNew York UniversityNew York, NY, United States 2019 Scientific Scholar Award Research in Focus: Novel therapies to treat ovarian cancer Targeting SHP2 and MEK in High-Grade Serous Ovarian Cancer High-grade serous ovarian cancer is the most lethal gynecological disease. Dr. Tang and colleagues have shown in that a combination treatment of SHP2 inhibitor […]
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Yael Raz Yana, MDCedars-Sinai Medical Center 2019 Cookie Laughlin Scholar Award Studying the Fallopian Tubes of BRCA Mutation Carriers to Understand the Infrastructure for Malignant Transformation Though the majority of ovarian cancer patients are postmenopausal, it is unknown how age and postmenopausal conditions contribute to cancer development. Women with inherited BRCA1 gene mutations are at […]
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Achuth Padmanabhan, PhDBaylor College of Medicine2019 Skacel Family Scholar PROTAC-mediated degradation of oncogenic gain-of-function p53 mutants: A personalized therapeutic strategy for ovarian cancer Ovarian cancer is the fifth leading cause for cancer-associated deaths among women in the US and is associated with frequent mutations in p53 gene. While some mutations result in the loss of […]
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Erin George, MDUniversity of Pennsylvania2019 Lynda’s Fund Scholar Award Strategies to optimize drug tolerability without compromising efficacy Most women with ovarian cancer present with advanced stage disease. Large surgeries and toxic chemotherapies are the mainstay of treatment and, despite advances in medicine, most ovarian cancers return. Every tumor is unique in its biology, allowing for […]
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Sarah Beth Gitto, PhDUniversity of Pennsylvania2019 Scientific Scholar Award Priming the TME with anti-VEGF to enhance the efficacy of dual checkpoint inhibition in PARPi-resistant OC Recent studies have shown that the use of the PARP inhibitor olaparib increases survival of ovarian cancer. Unfortunately, most patients will become resistant to PARP inhibitors, thus novel treatment strategies […]
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Rosana Risques, PhDUniversity of Washington Development of a multi-gene uterine lavage test for ovarian cancer detection Ovarian cancer is deadly because it is usually detected at advanced stage. Survival for advance stage ovarian cancer is only 25%, compared to 90% for early stage cancer, which indicates that ovarian cancer can be cured if detected early. […]
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Hui Zong, PhDUniversity of VirginiaCharlottesville, VA, United States 2019 Pilot Study Award Research in Focus: Prevention of ovarian cancer Efficacy testing for ovarian cancer prevention at pre-malignant stages with a novel mouse model Prevention remains the ultimate goal for successful management of cancer. Identifying cancer prevention strategies is challenging due to the large population required to […]
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Wa Xian, PhDUniversity of Texas Health Science Center at HoustonHouston, TX, United States 2019 Pilot Study Award Research in Focus: Understanding and overcoming resistance to chemotherapy Resistant Cancer Stem Cell Profile in Multi-Site Metastasis of HGSC Even though ovarian cancer is typically detected very late, advances in surgery and chemotherapy have resulted in remarkable responses in […]
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Amy Patrice Skubitz, PhDUniversity of Minnesota – Twin CitiesMinneapolis, MN, United States 2019 Cookie Laughlin Pilot Study Award Research in Focus: Early detection of ovarian cancer Validation of a multi-protein classifier for detecting early stages of ovarian cancer Early detection of ovarian cancer is needed to increase patient survival by identifying the disease when it is […]
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Sachdev Sidhu, PhDUniversity of TorontoToronto, Ontario, Canada 2019 Pilot Study Award Research in Focus: Novel therapies to treat ovarian cancer Targeting Ephrin receptors with antibody-drug conjugates to design novel treatments for ovarian cancer Alterations in certain proteins located on the surface of cells, known as receptor proteins, can lead to the formation of tumors. These receptor […]
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