Weei-Chin Lin, MD, PhD Baylor College of Medicine Houston, Texas Novel approaches to target MYC in ovarian cancer Many ovarian cancers express the cancer-causing MYC protein at unusually high levels. The activation of MYC is a hallmark of cancer initiation, progression, and resistance to therapy. Unfortunately, MYC is one of the most difficult proteins to […]
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Tao Wu, PhDBaylor College of Medicine2020 Scientific Scholar Award Targeting Epigenetic Landscape Reprogramming to Combat Drug-resistance in Ovarian Cancer Despite major improvements in therapeutic approaches to ovarian cancer, the ability of tumors to develop resistance to anti-cancer drugs remains the major challenge in achieving longer-lasting remission. One of the ways drug resistance is thought to […]
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Achuth Padmanabhan, PhDBaylor College of Medicine2019 Skacel Family Scholar PROTAC-mediated degradation of oncogenic gain-of-function p53 mutants: A personalized therapeutic strategy for ovarian cancer Ovarian cancer is the fifth leading cause for cancer-associated deaths among women in the US and is associated with frequent mutations in p53 gene. While some mutations result in the loss of […]
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Fang-Tsyr Lin, MD, PhDBaylor College of Medicine RIP6 Regulates p27KIP1 to Promote Ovarian Tumorigenesis The CDK inhibitor p27KIP1 is traditionally viewed as a tumor suppressor by inhibiting cell cycle progression. However, the cytosolic mislocalized p27KIP1 can induce ovarian cancer cell invasion. Dr. Lin has shown that these opposing effects are regulated through the interaction of […]
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Weei-Chin Lin, MD, PhDBaylor College of Medicine Target a new mechanism of checkpoint defect in ovarian cancer Normal cellular growth is regulated by a process called replication checkpoint. Most ovarian cancers contain the tumor suppressor p53 that is mutated and therefore interferes with proper replication checkpoint function. Dr. Lin’s preliminary data uncovered a novel activity […]
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Martin Matzuk, MD, PhDBaylor College of Medicine 2013 Challenge Grant Award Recipient Molecular Imaging of the Dicer/Pten Mouse Model Tumor Microenvironment Dr. Matzuk’s project will use Dicer-Pten mutant mice, which closely model human high-grade serous carcinoma with tumors arising in the fallopian tubes. A state-of-the-art tissue-based mass spectrometry imaging platform will provide the approach for […]
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