Hua E Yu, PhDBeckman Research Institute of the City of Hope2020 Karla Mooers Pilot Study Award Targeting dePARylation activates anti-ovarian cancer immune responses The FDA has approved several types of PARP inhibitors for treating ovarian cancer. These drugs are especially effective at killing tumor cells that cannot repair damage that occurs to their DNA. One […]
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Jeremy Stark, PhDBeckman Research Institute of the City of Hope Homology-Directed Repair Deficiency in Ovarian Cancer Cancer cells that are able to perform homology-directed repair (HDR) can be resistant to PARP inhibitor therapeutics, which are purposefully designed to cause DNA damage. Many ovarian cancers apparently lack the HDR pathway, and hence are likely to be […]
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