Yael Raz Yana, MDCedars-Sinai Medical Center 2019 Cookie Laughlin Scholar Award Studying the Fallopian Tubes of BRCA Mutation Carriers to Understand the Infrastructure for Malignant Transformation Though the majority of ovarian cancer patients are postmenopausal, it is unknown how age and postmenopausal conditions contribute to cancer development. Women with inherited BRCA1 gene mutations are at […]
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Sandra Orsulic, PhDCedars-Sinai Medical Center Determinants of Drug Sensitivity in BRCA Deficient Cells: The Role of TUBB4 in Resistance to Paclitaxel Currently, post-operative chemotherapy for patients with sporadic and BRCA-associated ovarian cancers includes treatment with taxanes and platinum. However, there is an indication that patients with BRCA-associated cancers respond less favorably to taxanes. Dr. Orsulic […]
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Christine Walsh, MDCedars-Sinai Medical Center Genetic Modifiers of BRCA1-Associated Gynecologic Cancer Penetrance Women who inherit a mutation in the BRCA1 gene have a 40% risk of developing ovarian, tubal, or peritoneal cancer. Dr. Walsh is seeking to shed light on genetic and molecular events that lead to tumor development in some women in this high-risk […]
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