Melissa Fishel, PhDIndiana University School of Medicine Enhancement of ovarian cancer to chemotherapeutics agents, cisplatin and TMZ, using small molecules, BG and MX With the exception of a small percentage of patients presenting with stage IA/IB ovarian cancer, surgery along is inadequate treatment. However, virtually all patients who die from ovarian cancer have intrinsic or […]
Read MoreDaniela Matei, MDIndiana University Atransglutaminase 2 Modulates Sensitivity to Chemotherapy in Ovarian Cancer The most significant cause of death and illness related to ovarian cancer is its propensity to spread in the abdomen. However, the mechanisms responsible for spread are not known. We discovered that an enzyme called transglutaminase 2 (TG2) is present at high […]
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Karen Cowden Dahl, PhDIndiana University The Role of ARID3B isoforms in Ovarian Cancer and Chemoresistance Around 70% of women diagnosed with ovarian cancer have advanced disease and the prognosis is very poor. Treatment for ovarian cancer consists of surgery followed by chemotherapy. One of the contributing factors to the poor prognosis for advanced ovarian cancer […]
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Anirban Mitra, PhDIndiana University Microenvironment Induced Epigenetic Regulation in Ovarian Cancer The spreading of cancer cells from the primary ovarian tumor to distant organs within the abdomen is the most critical step in ovarian cancer. Yet it remains the least understood aspect of the disease. Using unique and clinically relevant experimental models, including primary human […]
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Shannon Hawkins, M.D., Ph.D.Indiana UniversityIndianapolis, IN, United States Project: Dissecting the role of ARID1A in ovarian cancer using a 3D bio-assembled model of the endometriotic tumor microenvironment Research Areas: Cancer Biology Summary:Endometriosis, growth of uterus tissue outside the uterus, effects 5 million women in the US and is associated with a 50% increase in the risk of […]
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