Christina Annunziata, MD, PhDNational Cancer Institute Characterization of NF-kB signaling as a therapeutic target in ovarian cancer The NF-kB family of transcription factors has been implicated in the increase of ovarian cancer cell lines, but the significance and the mechanism of signaling is unknown. Initial experiments identified a subset of ovarian cancer cell lines that […]
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Anne Noonan, MB BCh BAO, MSc, MRCPINational Cancer Institute2012 Gilman Family Scholar Proteomic biomarker development for optimal sequencing of doxetaxel & SMACmimetic The drug TL32711 can stimulate ovarian cancer cell death by decreasing proteins that inhibit cell death and decreasing signaling through the NFkB signalling pathway that is known to be overactive in ovarian cancer. […]
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