Ilona Kryczek, PhDUniversity of Michigan IL-17+ T cells in patients with ovarian cancer T helper cells (Th), a sub-group of white blood cells, play a crucial role in inflammatory responses and autoimmune diseases, but are poorly understood in human pathology. By using our well-established human ovarian cancer model, we propose to map out the basic […]
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Ilona Kryczek, PhDUniversity of Michigan Human myeloid suppressor cells maintain ovarian cancer stemness Stem-like cancer cells are thought to play a key role in both chemoresistance and relapse, both of which can occur following treatment of advanced ovarian cancer. Stem-like cancer cells are maintained and supported by niches enriched in immune cells. Dr. Kryczek’s project […]
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Geeta Mehta, PhDUniversity of Michigan Shear stress modulates invasiveness, tumorigenicity, and immune responses in ovarian stem cells The ovarian cancer environment in the abdominal cavity is quite complex, as cancer cells exist among cancer progenitor cells and immune cells in the ascites fluid. The physical stress from fluid movement and interactions with other cells likely […]
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