Mark Gavin, MD, PhDUniversity of Minnesota A genetic screen for epithelial ovarian cancer genes With over 80 genes and 200 transcripts implicated in the development of ovarian cancer, there are little similarities among ovarian cancer. It is the goal of this study to identify those genes that are singularly critical to the genesis of the […]
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Faris Farassati, PhD, PharmDUniversity of Minnesota A Novel Strategy for Targeting Ovarian Cancer Mesothelin is a plasma membrane antigen expressed in significantly high levels in mesothelioma and ovarian cancer patients. This study will test the hypothesis that ovarian cancer cells are biologically dependent on the expression of mesothelin for their survival. The results will provide […]
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Ilana Chefetz, PhDUniversity of Minnesota, Twin Cities Deciphering molecular mechanism of ALDH-inhibition driven necroptosis Dr. Chefetz-Menaker recently demonstrated that chemotherapy resistant ovarian cancer stem-like cells (CSC) can be identified by a protein activity known as ALDH. The expression of ALDH in CSC allows a unique opportunity to develop therapeutics specifically targeting CSC, which are thought […]
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