Mary Zhang, PhDUniversity of South Florida Role of HDAC6 and its novel substrate cortactin in ovarian cancer cell motility HDACs are a group of enzymes that regulate cell growth and migration, and hence are likely involved with the metastases of ovarian cancer. This study will examine the role between these enzymes and the molecular events […]
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Patricia Kruk, PhDUniversity of South Florida Elevated Urinary Bcl-2 in Ovarian Cancer This study seeks to determine whether a simple urine test for a protein called Bcl-2 may serve as a new biomarker for detection of ovarian cancer.
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Xiaohong (Mary) Zhang, PhDUniversity of South Florida, College of Medicine Mechanisms by which HDAC inhibitors sensitize cisplatin resistant ovarian cells Overcoming platinum-resistance in ovarian cancer patients remains a great challenge. Recently, histone deacetylase (HDAC) inhibitors are being used to minimize resistance. HDAC6 may confer the cisplatin-resistance by down-regulating a DNA repair complex. Dr. Zhang will […]
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Meera Nanjundan, PhDUniversity of South Florida Role of Autophagy in the Transition from Endometriosis to Ovarian Cancers Dr. Nanjundan proposes that endometriosis, an inflammatory gynecological disease, is a “precursor lesion” leading to the development of endometrioid/clear cell ovarian cancers. Although less frequent relative to serous ovarian cancers, often the prognosis is worse. This project will […]
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