Andrew Wilson, PhDVanderbilt University Medical Center The Role of the Nuclear Orphan Receptor TR3/Nur77 in Ovarian Cancer Preliminary results have led to the hypothesis that TR3 is a marker of chemotherapy-induced apoptosis and a potential therapeutic target in ovarian cancer. In this study, three aims will be investigated by Dr. Wilson and his team. First, […]
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Andrew Wilson, PhDVanderbilt University Prognostic Significance of TR3/NR4A1 Expression in Ovarian Cancer A key clinical problem in the management of advanced ovarian cancer is tumor resistance to traditional platinum drugs and to newer drugs that inhibit the PARP protein (PARPi). Dr. Wilson will investigate an innovative approach to improve the effects of platinum drugs and […]
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Fiona Yull, D.Phil.Vanderbilt University Bromodomain inhibition in ovarian cancer and the tumor microenvironment Scientists are actively working to find new therapies for ovarian cancer as resistance to current therapies, including PARP inhibitors and cisplatin, poses a major problem in the clinic. One promising approach is to develop strategies that activate the patient’s normal immune system […]
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