Hector Franco, PhDUniversity of North Carolina, Chapel Hill2022 Lester and Bernice Smith Pilot Study Award Identifying Drivers of Therapeutic Resistance in Ovarian Cancer at Single-Cell Resolution Ovarian cancer is one of the deadliest cancers among women worldwide. Most women respond well to the standard treatment; however, up to 75% of these patients experience a recurrence […]
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Tao Wu, PhDBaylor College of Medicine2020 Scientific Scholar Award Targeting Epigenetic Landscape Reprogramming to Combat Drug-resistance in Ovarian Cancer Despite major improvements in therapeutic approaches to ovarian cancer, the ability of tumors to develop resistance to anti-cancer drugs remains the major challenge in achieving longer-lasting remission. One of the ways drug resistance is thought to […]
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Mary Zhang, PhDUniversity of South Florida Role of HDAC6 and its novel substrate cortactin in ovarian cancer cell motility HDACs are a group of enzymes that regulate cell growth and migration, and hence are likely involved with the metastases of ovarian cancer. This study will examine the role between these enzymes and the molecular events […]
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Capucine Van Rechem, PhDMassachusetts General Hospital2014 Skacel Family Scholar Copy Gain and Resistance: Uncovering Roles for Epigenetic Regulation in Ovarian Cancer A major issue in the treatment of ovarian cancer is the development of resistance to standard chemotherapy. Such drug resistance has been linked to the gain of a specific genomic region, 1q12-1q21. Dr. Van […]
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Victor Levenson, MD, PhDNorthwestern University A Composite DNA Methylation Biomarker For Ovarian Cancer Detection This study seeks to find a blood-based DNA pattern (as opposed to a single specific target) that could be used to detect ovarian cancer early.
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Dusica Cvetkovic, MDFox Chase Cancer Center Validation of an ovarian cancer biomarker panel in high-risk women This study will examine ovaries removed during prophylactic (preventative) surgery, before ovarian cancer is discovered or suspected. The hypothesis is that aberrant DNA methylation can be detected in the blood of women prior to the onset of clinical symptoms. […]
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Ilona Kryczek, PhDUniversity of Michigan Human myeloid suppressor cells maintain ovarian cancer stemness Stem-like cancer cells are thought to play a key role in both chemoresistance and relapse, both of which can occur following treatment of advanced ovarian cancer. Stem-like cancer cells are maintained and supported by niches enriched in immune cells. Dr. Kryczek’s project […]
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Anirban Mitra, PhDIndiana University Microenvironment Induced Epigenetic Regulation in Ovarian Cancer The spreading of cancer cells from the primary ovarian tumor to distant organs within the abdomen is the most critical step in ovarian cancer. Yet it remains the least understood aspect of the disease. Using unique and clinically relevant experimental models, including primary human […]
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Christopher J. Kemp, PhDFred Hutchinson Cancer Research Center 2019 Sequoyah Electric Pilot Study Award Preclinical advancement of combination therapy targeting BAZ2A and EZH2 in ovarian clear cell carcinoma Ovarian cancer accounts for over 14,000 deaths in the United States every year. Although ovarian cancer has several subtypes, patients have been treated almost in the same […]
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