Hong Zhang, PhDFox Chase Cancer Center Regulated exocytosis and gamma synuclein in ovarian cancer: a biomarker of disease γ synuclein (gamma synuclein) is a protein that may shuttle other proteins which promote the growth and spread of cancer. This study will identify these protein promoters and assess whether γ synuclein could be used in screening.
Read More
Jill Slack-Davis, PhDUniversity of Virginia Role of VCAM-1 in an orthotopic mouse model of ovarian cancer metastasis It is believed that the vascular cell adhension molecule-1 (VCAM-1) aids in the adhesion and spreading of ovarian cancer in the abdomen and beyond. By defining the role of VCAM-1, this work could lead to a target for […]
Read More
Shu-Wing Ng, PhD, BScHarvard / Brigham and Women’s Hospital Characterization of lipid metabolic enzymes in ovarian cancer This study will confirm the expression and activity of two important enzymes and investigate the effects of inhibiting these enzymes. The results will provide information regarding their role in ovarian cancer and have an impact on screening, surveillance […]
Read More
Lainie Martin, MDFox Chase Cancer Center A pilot study to evaluate the role of STAT3 in angiogenesis, tumor cell proliferation and survival in ovarian cancer This study will look at a family of genes (STAT3) and their impact on the process of cell death. With a greater understanding the role of STAT3, researchers hope to […]
Read More
Zhiyong Ding, PhDThe University of Texas MD Anderson Cancer Center Identification of novel interaction partners of p110 and p85 in ovarian cancer cells Ovarian cancer, like all cancer, is a disease of gene malfunctions. This study will look at a gene known to control cancer cells (PIK3CA) and the proteins it interacts with. These proteins […]
Read More
Kwong-Kwok Wong, PhDUniversity of Texas MD Anderson Cancer Center To investigate invasion determinants in low-grade ovarian serous cancer Low-grade ovarian serous carcinomas (OSCs) appear to be a continuum from borderline tumors, and is often resistance to chemotherapy. The possible progression from borderline tumor to low-grade OSC will involve the acquisition of the ability to invade […]
Read More
Terry Van Dyke, PhD and Vickie Bae-Jump, MD, PhDThe University of North Carolina at Chapel Hill A Pathway to Therapeutic Treatment and Early Detection of Ovarian Cancer This project will compare global gene expression patterns across human and a novel genetically engineered mouse model of epithelial ovarian cancer in order to identify relevant molecular pathways […]
Read More
Alexander Nikitin, MD, PhDCornell University Role of miR-34 in ovarian cancer MicroRNAs are a recently discovered class of genes, important for regulation of critical proteins in the cell. We have identified a family of p53-regulated microRNAs (p53 is a protein central to many of the cell’s anti-cancer mechanisms) that are found at reduced levels in […]
Read More
Mark Gavin, MD, PhDUniversity of Minnesota A genetic screen for epithelial ovarian cancer genes With over 80 genes and 200 transcripts implicated in the development of ovarian cancer, there are little similarities among ovarian cancer. It is the goal of this study to identify those genes that are singularly critical to the genesis of the […]
Read More
Faris Farassati, PhD, PharmDUniversity of Minnesota A Novel Strategy for Targeting Ovarian Cancer Mesothelin is a plasma membrane antigen expressed in significantly high levels in mesothelioma and ovarian cancer patients. This study will test the hypothesis that ovarian cancer cells are biologically dependent on the expression of mesothelin for their survival. The results will provide […]
Read More