Alice Soragni, Ph.D. University of California, Los Angeles Los Angeles, CA, United States 2018 LYNDA’S FUND PILOT STUDY AWARD Project: p53 aggregation in pre-malignant ovarian cancer lesions Research Area: Cancer Biology Summary:p53 is a crucial tumor suppressor protein that prevents damaged cells from becoming cancerous. In order to divide uncontrollably, cancer cells often inactivate p53 by mutating it, as […]
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Steven M Jay, Ph.D.University of Maryland College ParkCollege Park, MD, United States Engineering HER3-targeted ovarian cancer therapy The presence of the HER3 protein on the surface of ovarian cancer cells is associated with worse survival outcomes; therefore, blocking the pro-cancer activity of the HER3 protein may improve survival. Dr. Jay’s lab has developed a new […]
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Christopher J. Kemp, PhDFred Hutchinson Cancer Research Center 2019 Sequoyah Electric Pilot Study Award Preclinical advancement of combination therapy targeting BAZ2A and EZH2 in ovarian clear cell carcinoma Ovarian cancer accounts for over 14,000 deaths in the United States every year. Although ovarian cancer has several subtypes, patients have been treated almost in the same […]
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Lana Kandalaft, PhD University Medical School, Lausanne (CHUV)2019 Dearborn Family Pilot Study Award Development of personalized cancer vaccination strategies in ovarian cancer As ovarian cancer lacks specific symptoms, most patients are diagnosed at an advanced stage whereby treatment response is poor. One option for treatment is to activate the patient’s own immune system using individually […]
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Cecil Han, PhDGeorgetown University Understanding and Targeting Mitochondrial Heterogeneity in Ovarian Cancer High grade serous ovarian cancers are very complex and variable, making them difficult to treat. One source of this variability may be in the mitochondria, a cellular component known as the “powerhouse”, of ovarian cancer cells. Studies have shown that the variability in […]
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Caroline Ford, PhDUniversity of New South Wales2019 James A. Harting Pilot Study Award Research in Focus: Novel therapies to treat ovarian cancer Shock and ROR! Inhibiting ovarian cancer metastasis with targeted therapies in an organotypic model of ovarian cancer In order to improve survival in ovarian cancer, we need to further study the molecular changes at […]
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André Lieber, MD, PhDUniversity of Washington2016 Lester and Bernice Smith Challenge Award Grant Immuno-Prophylaxis of Ovarian Cancer Associated with High-Risk Germ Line Mutations Dr. Lieber’s project proposes a prophylactic gene therapy approach to introduce genes encoding antibodies into hematopoietic stem cells from the bone marrow. Ovarian cancer cells normally produce signals that inhibit immune cells […]
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