Elizabeth Swisher, MDUniversity of WashingtonSeattle, WA Optimizing genetic testing uptake and outcomes for hereditary ovarian cancer risk As genetic testing for cancer risk becomes increasingly accessible, the goal of eradicating hereditary ovarian cancer through comprehensive genetic testing and effective prevention is tantalizingly close. However, several large studies have revealed that a large minority of people […]
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Holly R. Harris, MPH, ScDFred Hutchinson Cancer CenterSeattle, WA Identification of ovarian cancer risk factors among women with endometriosis Although we know endometriosis increases ovarian cancer risk, we do not know how to identify which individuals with endometriosis will develop ovarian cancer. Dr. Harris will run the first large-scale analysis of women with endometriosis to […]
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Barbara Norquist, MDUniversity of Washington2013 Skacel Family Scholar Genes Contributing to Hereditary Ovarian Cancer in BRCA1/2 Wildtype Families Nearly a quarter of ovarian cancer cases may be caused by inherited mutations, with a significant portion caused by mutations in genes other than BRCA1 and BRCA2 (BRCA1/2). Next generation sequencing techniques have made it possible to […]
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Alice Wen-Ron Lee, Ph.D.California State University FullertonFullerton, CA, United States Project: Exploring the impact of infertility and its treatments on risk of ovarian cancer Research Area: Prevention, Cancer Biology Summary:Some studies have previously indicated that there may be a relationship between infertility and ovarian cancer risk, but this connection is very poorly understood. Infertility is a significant […]
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Carol Hanchette, PhDUniversity of Louisville Ovarian Cancer and Pulp and Paper Manufacturing in the US: A Geospatial Analysis The primary aim of Dr. Hanchette‘s project is to discover whether high rates of ovarian cancer occurrence in the United States correspond with the locations of pulp and paper mills. An association between the two has been […]
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Rosana Risques, PhDUniversity of Washington 2017 Pape Family Pilot Study Award Characterization of TP53 mutations in BRCA carcinogenesis Women with inherited mutations in the BRCA1 and BRCA2 genes have a greatly increased risk of developing high-grade serous ovarian cancer (HGSOC). This type of cancer starts as a lesion in the fallopian tube, and these lesions almost always contain cells […]
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John Liao, M.D., Ph.D.University of Washington2018 James A. Harting Pilot Study Award Development of a vaccine to prevent serous tubal intraepithelial carcinoma High grade serous ovarian cancer does not originate in the ovary, as once thought, but on the fallopian tube. Precancerous fallopian tube cells (called serous tubal intraepithelial carcinoma or STIC) can go through […]
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Susan J Ramus, PhDThe University of New South Wales Genetic susceptibility to non-high grade serous ovarian cancer Ovarian cancer consists of five distinct types of cancers that have different clinical characteristics, patient outcomes, and even begin in different nearby organs. They have different changes in the DNA of the tumor cells which affect the biology […]
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Hui Zong, PhDUniversity of VirginiaCharlottesville, VA, United States 2019 Pilot Study Award Research in Focus: Prevention of ovarian cancer Efficacy testing for ovarian cancer prevention at pre-malignant stages with a novel mouse model Prevention remains the ultimate goal for successful management of cancer. Identifying cancer prevention strategies is challenging due to the large population required to […]
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Keren Levanon, MD/PhDSheba Fund for Health Service and Research2019 Pilot Study Award Microbiome profiling unveils metabolic vulnerabilities of BRCA mutated ovarian cancer Recent studies have shown that fallopian tubes and other genital track tissues that were previously thought to be sterile actually contain bacteria. These bacteria are believed to cause chronic inflammation which can lead […]
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