Geeta Mehta, PhDUniversity of Michigan Shear stress modulates invasiveness, tumorigenicity, and immune responses in ovarian stem cells The ovarian cancer environment in the abdominal cavity is quite complex, as cancer cells exist among cancer progenitor cells and immune cells in the ascites fluid. The physical stress from fluid movement and interactions with other cells likely […]
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Shannon Hawkins, M.D., Ph.D.Indiana UniversityIndianapolis, IN, United States Project: Dissecting the role of ARID1A in ovarian cancer using a 3D bio-assembled model of the endometriotic tumor microenvironment Research Areas: Cancer Biology Summary:Endometriosis, growth of uterus tissue outside the uterus, effects 5 million women in the US and is associated with a 50% increase in the risk of […]
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Angela Russo, Ph.DUniversity of Illinois at Chicago – UICChicago, IL, United States2018 MARLYS CHENEY PILOT AWARD Project: Characterization and targeting the markers of stemness altered during ovarian cancer pathogenesis using WNT inhibitors Research Areas: Cell Biology, Stem Cells, Tumor Microenvironment Summary:High-grade serous ovarian cancer is the most common type of ovarian cancer with the highest mortality rate. […]
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Cecil Han, PhDGeorgetown University Understanding and Targeting Mitochondrial Heterogeneity in Ovarian Cancer High grade serous ovarian cancers are very complex and variable, making them difficult to treat. One source of this variability may be in the mitochondria, a cellular component known as the “powerhouse”, of ovarian cancer cells. Studies have shown that the variability in […]
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Martin Matzuk, MD, PhDBaylor College of Medicine 2013 Challenge Grant Award Recipient Molecular Imaging of the Dicer/Pten Mouse Model Tumor Microenvironment Dr. Matzuk’s project will use Dicer-Pten mutant mice, which closely model human high-grade serous carcinoma with tumors arising in the fallopian tubes. A state-of-the-art tissue-based mass spectrometry imaging platform will provide the approach for […]
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