Northwest Gynecological Cancer Symposium
Northwest Gynecological Cancer Symposium
Wednesday, September 25th, 2019
8:00 AM – 7:00 PM
SEATTLE, WA
The Rivkin Center is proud to present the 2nd biennial Northwest Gynecological Cancer Symposium (NGCS) to be held on Wednesday, September 25th, 2019 from 8:00am to 6:30pm at Orin Smith Auditorium at the University of Washington, South Lake Union Campus in Seattle, Washington. NGCS is designed to facilitate communication and foster collaboration between scientists in the Pacific Northwest working on the prevention, early detection, and treatment of gynecological cancers.
Abstracts were submitted on basic science, preclinical, clinical and public health projects on gynecological research, including the following research areas: animal models, biomarkers, cancer stem cells, cell biology, chemoresistance, clinical research, DNA repair & response, early detection, epigenetics, etiology/pathophysiology, genetics, genomics, immunology, molecular mechanisms, novel therapies, prevention, proteomics/metabolomics, survivorship, tumor microenvironment, and other topics relevant to gynecological cancer research.
Abstract submission is now closed.
Keynote Address
Defining the trajectory of ovarian cancer from early tubal precursors
Ronny Drapkin, MD/PhD
Franklin Payne Associate Professor of Pathology in Obstetrics & Gynecology
Perelman School of Medicine, University of Pennsylvania
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NGCS Flyer
Download the NGCS flyer to share with colleagues or post on message boards.
Free Registration
The symposium is open to all. The FREE registration is required to partake in catered lunch and reception. Online registration closes on September 18th. Registration is limited to 120 participants. Limited day of registration will be available on a first come first served basis.
Location
NGCS will be held in the Orin Smith Auditorium located in the Administrative Building (see street map and building map) at the University of Washington, South Lake Union at 850 Republican Street, Seattle, WA 98109.
Parking
Parking is available at UW SLU garages. The entrances to both garages is on Republican St. Hourly and daily rates are offered (payment by Visa/MasterCard only). Parking for 4 or more hours costs $21. For UW employees, parking in the SLU garages is free if you have a UW parking pass. Garage parking is free to all after 3:30pm. Please note that you cannot ENTER the garage after 5:30pm, but you can exit at any time.
The garage elevator will take you directly to the reception desk (opens onto the lobby).
NOTE: You will need to have your ticket validated at the reception desk in order to leave the garage (the arm at the exit will not raise without it).
Contact
Jackie Lang, PhD at Jackie.Lang@Swedish.org
Program
8:00am – 8:30am
8:30am – 8:40am
4:00 PM – 4:15 PM
Opening Remarks by Kiran Dhillon, PhD, Rivkin Center
SESSION I: DETECTION AND PREVENTION
Moderator
Rosana Risques, PhD (2017 Pape Family Pilot Study Award; 2019 Rivkin Bridge Funding Award)
8:40am – 8:55am
Characterization of TP53 mutations in Pap test DNA of women with and without serous ovarian cancer
Rosana Risques, PhD, University of Washington
8:55am – 9:10am
The effect of OCP use on the incidence of pre-cancerous p53 lesions in fallopian tube fimbria
Kendall Greening, MSc, BC Cancer Research Centre
9:10am – 9:25am
Clinical tissue proteomics identifies new mesonephric carcinoma biomarkers
Evan Gibbard, University of British Columbia
9:25am – 9:40am
Ethnic disparity in detection of ovarian malignancy
Chares Dunton, MD, ASPiRA Labs
9:40am – 10:10am
Coffee Break
SESSION II: CANCER MECHANISMS
Moderator
Bo Yu, MD (2017 Cookie Laughlin Bridge Funding Award)
10:10am – 10:25am
Modelling initiation events of low-grade serous ovarian cancers with organoid cultures and single cell sequencing
Joyce Zhang, BC Cancer Research Centre
10:25am – 10:40am
Targeted next-generation sequencing identifies mutations in epigenetic regulators in a large cohort of adult-type granulosa cell tumors
Jessica Pilsworth, University of British Columbia
10:40am – 10:55am
Single cell RNA sequencing of normal endometrial organoids reveals prognostic markers in gynecologic tumors
Dawn Cochrane, PhD, BC Cancer Research Centre
10:55am – 11:00am
Keynote Introduction by Mark Carey, MD
11:00am – 12:00pm
Keynote Address
Defining the trajectory of ovarian cancer from early tubal precursors
Ronny Drapkin, MD/PhD, University of Pennsylvania
12:00pm – 1:00pm
Lunch (provided)
12:00pm – 1:00pm
Trainee Lunch with Keynote Speaker
SESSION III: MANAGEMENT AND RESOURCES
Moderator
Robyn Andersen (2017 Pilot Study Award)
1:00pm – 1:15pm
Piloting a meditation intervention for ovarian cancer survivors to change Heart Rate Variability (HRV)
Robyn Andersen, PhD, Fred Hutchinson Cancer Research Center
1:15pm – 1:30pm
Quality improvement assessment of a standardized multidisciplinary approach to prescribing PARP inhibitors
Amy Indorf, PharmD, University of Washington/Seattle Cancer Care Alliance
1:30pm – 1:45pm
Improving findability of gynecological biospecimens and associated data through the Cascadia Data Discovery Initiative
Brenda Kostelecky, PhD, Cascadia Data Alliance at Fred Hutch
1:45pm – 2:10pm
Poster Presentation Lightning Round
2:10pm – 2:40pm
Coffee Break
SESSION IV: THERAPEUTICS
Moderator
Andre Lieber, MD/PhD (2010 Pilot Study Award; 2016 Lester and Bernice Smith Challenge Grant)
2:40pm – 2:55pm
Prophylactic in vivo hematopoietic stem cell gene therapy with an immune checkpoint inhibitor reverses tumor growth in syngeneic mouse tumor models
Andre Lieber, MD/PhD, University of Washington
2:55pm – 3:10pm
Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in solid tumors
Kristin Anderson, PhD, Fred Hutchinson Cancer Research Center
3:10pm – 3:25pm
The immune and tumor metabolic ecosystem in human ovarian cancer
Julian Lum, PhD, BC Cancer Research Centre
3:25pm – 3:40pm
Inflammatory response in endometrial carcinoma is associated with tumor phenotype and host exposures in the Nurses’ Health Study
T. Rinda Soong, MD/PhD, University of Washington
3:40pm – 3:45pm
Closing Remarks by Nora Disis, MD
3:45pm – 5:00pm
Poster Session
5:00pm – 6:30pm
RECEPTION
POSTERS
A CLIA certified functional precision medicine assay, the PARIS© test, to predict drug response for ovarian cancer
Carla Grandori, MD/PhD, SEngine Precision Medicine
Single-cell sequencing to investigate the cellular origins of endometrium-derived ovarian carcinomas
Germain C. Ho, BC Cancer Research Centre
CDK4/6 and MEK inhibitor combination in low-grade serous ovarian cancer cell lines
Joshua Hoenisch, University of British Columbia
Potential for vitamin D in the prevention of ovarian cancer in women with BRCA1 mutations
Sonali Joshi, PhD, Oregon Health and Science University
Single cell proteomic analysis of the tumoral heterogeneity in response to PARP inhibitor
Marilyne Labrie, PhD, Oregon Health and Science University
Targeting FANCD2 increases chemosensitivity of ovarian cancer cells
Tanja Pejovic, MD/PhD, Knight Cancer Institute / Oregon Health and Science University
Selective killing of SMARCA4-deficient ovarian cancer by mitochondria respiration inhibitors
Yemin Wang, PhD, BC Cancer Research Centre
Microbiome profiling of fallopian tubes
Bo Yu, MD, University of Washington
Location
NGCS will be held in the Orin Smith Auditorium located in the Administrative Building (see street map and building map) at the University of Washington, South Lake Union at 850 Republican Street, Seattle, WA 98109.
Parking
Parking is available at UW SLU garages. The entrances to both garages is on Republican St. Hourly and daily rates are offered (payment by Visa/MasterCard only). Parking for 4 or more hours costs $21. For UW employees, parking in the SLU garages is free if you have a UW parking pass. Garage parking is free to all after 3:30pm. Please note that you cannot ENTER the garage after 5:30pm, but you can exit at any time.
The garage elevator will take you directly to the reception desk (opens onto the lobby)
ACCOMMODATIONS
We have arranged for a special group rate for the Hampton Inn & Suites which is a 10 minute walk from the symposium venue.
Hampton Inn and Suites Seattle-Downtown
700 5th Ave N
Seattle, WA 98109
(206)282-7700
Our NGCS Group Rate is $219 for a King or Two Queen Bed Guestroom. Rates are non-commissionable exclusive of state and local taxes and fees. Cancellation policies apply. The Rivkin Center will not reimburse penalties for late cancellations.
Please note the group rate is available as long as the hotel has availability, on a first come first serve basis. The rate extends to three nights before and after the night of September 24th as long as there is availability.
Online Reservation Instructions
If you are booking before September 1st, click on our group link and follow the instructions. You may also book through their website.
- Under “BOOK A ROOM” on the left hand side, select your dates.
- Click on “Add special rate codes” and enter in our Group Code “RC1”.
- Click on “Check Rooms and Rates”.
- Select the room you would like and complete the booking with your personal information.
Phone Reservation Instructions
If you are booking on or after September 1st, call the Hampton directly at (206)282-7700 and ask for Ashton. Tell her you are with the Rivkin Group and she will assist you with making your reservation using our Group Rate.
PARKING
Parking is available at the Hampton for $15 per day. There is also limited free street parking nearby.
TRANSPORTATION BETWEEN SEATTLE AND SEA-TAC AIRPORT
Link Light Rail
The easiest and most economical way to get from the airport to Seattle is on the Link Light Rail. From baggage claim, follow signs to the Link Light Rail. Ticket machines will be on your way to the platform and they accept cash, Visa, or MasterCard. The fare to get from Sea-Tac to any of the downtown stations is $3. Chose the train heading toward Seattle & University of Washington.
* Note that trains do not run between 1am and 5am on weeknights. See here for hours.
Ride Shares & Taxis
To use a ride share app (Uber, Lyft, or Wingz) to get from Sea-Tac airport to Seattle, schedule the ride as usual in the app and follow signs to the App Based Ride Share Pick-up Area at the airport. To catch a metered taxi (206-242-6200) or flat rate taxi (206-242-8800), follow signs to Ground Transportation.
TRANSPORTATION WITHIN SEATTLE
The “OneBusyAway” app provides real time arrival information for buses, the Link light rail, and the Streetcar. Each bus stop should also have a poster indicating approximate arrival times for each route.
Buses
Fare is $2.75 and exact change is required upon boarding. Ask your driver for a transfer ticket which will allow you to use King County Metro bus lines as needed for the next two hours.
South Lake Union Streetcar
The Streetcar runs between the Fred Hutchinson Cancer Research Center and downtown Seattle at 10-15 minute intervals. Fare is $2.25 and the pay stations located at every streetcar stop accept credit cards or coins. See here for hours.
Stops nearest the Symposium venue (UW SLU campus):
- Northbound streetcar (from downtown): Terry Ave N and Republican St
- Southbound streetcar (from Fred Hutch): Westlake Ave N and Mercer St
Ride Shares & Taxis
Uber and Lyft are very popular in Seattle. Alternatively, traditional taxi services are available: Yellow Cab (206-622-6500), Orange Cab (206-522-8800).
Sponsorship Opportunities
The Rivkin Center gratefully acknowledges our sponsors for the 2019 Northwest Gynecological Cancer Symposium. Without their vital underwriting and dedication, this event would not be possible. Thank you!
For more information about sponsoring this year’s event, please review the sponsorship packet or contact Julie Anderson, Development Manager, at julie.anderson@swedish.orgor (206) 215-6044.
Gold Sponsor
Silver Sponsor
Bronze Sponsor
NGCS Planning Committee
Mark Carey, MD
University of British Columbia
Kiran Dhillon, PhD
Rivkin Center
Nora Disis, MD
University of Washington / Fred Hutch
Frances Balkwill, PhD (Co-Chair)
Rivkin Center
Mary L. (Nora) Disis, MD (Co-Chair)
Oregon Health and Science University
Free Registration
The symposium is open to all. The FREE registration is required to partake in catered lunch and reception. Online registration closes on September 18th. Registration is limited to 120 participants. Limited day of registration will be available on a first come first served basis.
