Jean-Bernard Lazaro, PhD
Jean-Bernard Lazaro, PhDDana-Farber Cancer Institute Targeting DNA repair genes and the nucleolar proteome to increase cisplatin sensitivity in ovarian cancer Patients with ovarian cancer who are treated with cisplatin often develop resistance to the drug, as cisplatin acts by damaging cellular DNA, which in turn induces apoptosis. Repair of cisplatin-induced DNA damage by a few […]
Keren Levanon, MD, PhD
Keren Levanon, MD, PhDDana-Farber Cancer Institute The Fallopian Tube as field of origin of ovarian serous carcinoma Research on ovarian carcinogenesis has traditionally focused on the ovarian surface epithelium as the fields of origin. More recently, the secretory cell of the fallopian tube has emerged as an alternate cell-of-origin for ovarian and pelvic serous carcinomas, […]
Christina Annunziata, MD, PhD
Christina Annunziata, MD, PhDNational Cancer Institute Characterization of NF-kB signaling as a therapeutic target in ovarian cancer The NF-kB family of transcription factors has been implicated in the increase of ovarian cancer cell lines, but the significance and the mechanism of signaling is unknown. Initial experiments identified a subset of ovarian cancer cell lines that […]
Shailendra Giri, PhD
Shailendra Giri, PhDMayo Clinic S-nitrosylation mediated inactiviation of TSG in ovarian cancer Chronic inflammation has become a well-accepted risk factor for epithelial-derived malignancies, including ovarian cancer. But how inflammation contributes to the process of carcinogenesis is a grey area. If successful, Dr. Giri’s study will elucidate the possible novel regulation of chemical inactivation of LKB1-AMPK […]
Elda Righi, MD
Elda Righi, MDMassachusetts General Hospital Blockade of the CXCL12 and VEGF axes in ovarian cancer One of the reasons ovarian cancer progresses with few evident symptoms may be the combination of ways in which the cancer escapes the patient’s immune system and organizes a vascular supply to serve its own needs. CXCL12 and VEGF are […]
Amelie Margarete Lutz, MD, PhD
Amelie Margarete Lutz, MD, PhDStanford University2009 Gilman Family Scholar Early Detection of Ovarian Cancer Using Targeted Microbubble-Enhanced Ultrasound The primary objective of Dr. Lutz’s proposal is to validate and refine molecularly targeted microbubble contrast enhanced ultrasound (CEUS) for non-invasive, in-vivo imaging of the ovarian cancer-related angiogenesis. Like other solid tumors, ovarian cancer is critically dependent […]
Masafumi Toyoshima, MD, PhD
Masafumi Toyoshima, MD, PhDFred Hutchinson Cancer Research Center Identification of Targeted Therapies for MYC-Amplified Ovarian Cancer By Functional Genomics The main goal of Dr. Toyoshima’s research is to investigate whether MYC synthetic lethal genes can be therapeutic targets for ovarian cancer in women whose MYC gene is amplified. Using a siRNA screening strategy this study […]
Melissa Thompson, PhD
Melissa Thompson, PhDUniversity of Texas MD Anderson Cancer Center The Role of the Tumor Microenvironment in Ovarian Cancer Progression Ovarian cancer is the deadliest gynecological cancer, accounting for 15,520 deaths annually. Preliminary studies by Dr. Thompson indicate that the tumor microenvironment enables and promotes tumor progression and chemoresistance, possibly through the expression of SFRP2. With […]
Melissa Thrall, MD
Melissa Thrall, MDUniversity of Washington A population based evaluation of the use and outcomes of neoadjuvant chemotherapy The current standard of care for the treatment of advanced stage ovarian cancer involves surgery with a maximal effort to remove all visible tumor followed by the administration of platinum based chemotherapy. However not all women with advanced […]
Ramandeep Rattan, PhD
Ramandeep Rattan, PhDMayo Clinic TCEAL7, a novel regulator of NFkB-IL-6/STAT3 pathway in ovarian cancer The causes of ovarian cancer are not well understood because of the complexity and the lack of understanding of the various genetic alterations in the development of ovarian cancer and its progression to chemoresistant disease. Dr. Rattan’s study is poised to […]