Paul Goodfellow, MS, PhDOhio State University Role of BRIP1 helicase missense mutations in ovarian cancer BRIP1 gene has recently been recognized as an ovarian cancer susceptibility gene, based primarily on discovery of mutations that result in a truncated, or shortened, BRIP1 protein that no longer functions properly. Most genetic variation in the BRIP1 gene, however, […]
Read MoreSimon Chu, PhDMonash University PPARgamma Activation Augments Anticancer Effects of XIAP Inhibition in Ovarian Granulosa Cell Tumors Granulosa cell tumors of the ovary arise due to dysfunction of the granulosa cells, which are support cells in the ovary, involved in ovulation and production of hormones. Dr. Chu will determine if using therapeutic drugs that act […]
Read MoreAlice Soragni, Ph.D. University of California, Los Angeles Los Angeles, CA, United States 2018 LYNDA’S FUND PILOT STUDY AWARD Project: p53 aggregation in pre-malignant ovarian cancer lesions Research Area: Cancer Biology Summary:p53 is a crucial tumor suppressor protein that prevents damaged cells from becoming cancerous. In order to divide uncontrollably, cancer cells often inactivate p53 by mutating it, as […]
Read MoreShannon Hawkins, M.D., Ph.D.Indiana UniversityIndianapolis, IN, United States Project: Dissecting the role of ARID1A in ovarian cancer using a 3D bio-assembled model of the endometriotic tumor microenvironment Research Areas: Cancer Biology Summary:Endometriosis, growth of uterus tissue outside the uterus, effects 5 million women in the US and is associated with a 50% increase in the risk of […]
Read MorePamela K Kreeger, Ph.D.University of Wisconsin-MadisonMadison, WI, United States Project: Role of P-selectin in transcoelomic spread of ovarian cancer Research Area: Cancer Biology, Novel Therapy Summary:In high grade serous ovarian cancer, metastasis or spread of the cancer occurs when tumor cells break away from the primary tumor, float through the fluid in the abdominal cavity, and attach […]
Read MoreAngela Russo, Ph.DUniversity of Illinois at Chicago – UICChicago, IL, United States2018 MARLYS CHENEY PILOT AWARD Project: Characterization and targeting the markers of stemness altered during ovarian cancer pathogenesis using WNT inhibitors Research Areas: Cell Biology, Stem Cells, Tumor Microenvironment Summary:High-grade serous ovarian cancer is the most common type of ovarian cancer with the highest mortality rate. […]
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