Investigating how ovarian cancer begins and progresses

Paul Goodfellow, MS, PhD

August 17, 2019

Paul Goodfellow, MS, PhDOhio State University Role of BRIP1 helicase missense mutations in ovarian cancer BRIP1 gene has recently been recognized as an ovarian cancer susceptibility gene, based primarily on discovery of mutations that result in a truncated, or shortened, BRIP1 protein that no longer functions properly. Most genetic variation in the BRIP1 gene, however, […]

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Simon Chu, PhD

August 17, 2019

Simon Chu, PhDMonash University PPARgamma Activation Augments Anticancer Effects of XIAP Inhibition in Ovarian Granulosa Cell Tumors Granulosa cell tumors of the ovary arise due to dysfunction of the granulosa cells, which are support cells in the ovary, involved in ovulation and production of hormones. Dr. Chu will determine if using therapeutic drugs that act […]

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Alice Soragni, Ph.D.

August 16, 2019

Alice Soragni, Ph.D.
University of California, Los Angeles
Los Angeles, CA, United States 2018 LYNDA’S FUND PILOT STUDY AWARD Project: p53 aggregation in pre-malignant ovarian cancer lesions Research Area: Cancer Biology Summary:p53 is a crucial tumor suppressor protein that prevents damaged cells from becoming cancerous. In order to divide uncontrollably, cancer cells often inactivate p53 by mutating it, as […]

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Shannon Hawkins, M.D., Ph.D.

August 16, 2019

Shannon Hawkins, M.D., Ph.D.Indiana UniversityIndianapolis, IN, United States Project: Dissecting the role of ARID1A in ovarian cancer using a 3D bio-assembled model of the endometriotic tumor microenvironment Research Areas: Cancer Biology Summary:Endometriosis, growth of uterus tissue outside the uterus, effects 5 million women in the US and is associated with a 50% increase in the risk of […]

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Pamela K Kreeger, Ph.D.

August 16, 2019

Pamela K Kreeger, Ph.D.University of Wisconsin-MadisonMadison, WI, United States Project: Role of P-selectin in transcoelomic spread of ovarian cancer Research Area: Cancer Biology, Novel Therapy Summary:In high grade serous ovarian cancer, metastasis or spread of the cancer occurs when tumor cells break away from the primary tumor, float through the fluid in the abdominal cavity, and attach […]

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Angela Russo, Ph.D

August 16, 2019

Angela Russo, Ph.DUniversity of Illinois at Chicago – UICChicago, IL, United States2018 MARLYS CHENEY PILOT AWARD Project: Characterization and targeting the markers of stemness altered during ovarian cancer pathogenesis using WNT inhibitors Research Areas: Cell Biology, Stem Cells, Tumor Microenvironment Summary:High-grade serous ovarian cancer is the most common type of ovarian cancer with the highest mortality rate. […]

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Keren Levanon, MD/PhD

August 16, 2019

Keren Levanon, MD/PhDSheba Fund for Health Service and Research2019 Pilot Study Award Microbiome profiling unveils metabolic vulnerabilities of BRCA mutated ovarian cancer Recent studies have shown that fallopian tubes and other genital track tissues that were previously thought to be sterile actually contain bacteria. These bacteria are believed to cause chronic inflammation which can lead […]

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Cecil Han, PhD

August 16, 2019

Cecil Han, PhDGeorgetown University Understanding and Targeting Mitochondrial Heterogeneity in Ovarian Cancer High grade serous ovarian cancers are very complex and variable, making them difficult to treat. One source of this variability may be in the mitochondria, a cellular component known as the “powerhouse”, of ovarian cancer cells. Studies have shown that the variability in […]

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Martin Matzuk, MD, PhD

August 16, 2019

Martin Matzuk, MD, PhDBaylor College of Medicine 2013 Challenge Grant Award Recipient  Molecular Imaging of the Dicer/Pten Mouse Model Tumor Microenvironment Dr. Matzuk’s project will use Dicer-Pten mutant mice, which closely model human high-grade serous carcinoma with tumors arising in the fallopian tubes. A state-of-the-art tissue-based mass spectrometry imaging platform will provide the approach for […]

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